Comparative determination of the efficacy of bispyridinium oximes in paraoxon poisoning
Keywords:
acute toxicity, mice, therapeutic efficacy
Abstract
The inability of standard therapy to provide adequate protection against poisoning by organophosphorus compounds (pesticides and/or nerve agents) motivated us to search for new, more effective oximes. We investigated the pharmacotoxicological properties of six experimental K-oximes (K027, K033, K048, K074, K075, and K203) in vivo. The therapeutic efficacy of K-oximes (at doses of 5 or 25 % of their LD50)combined with atropine was assessed in paraoxon-poisoned mice and compared with conventionally used oximes HI-6 and TMB-4. The bisoxime K074 was the most toxic (LD50=21.4 mg kg-1) to mice, while monoxime K027 was the least toxic (LD50=672.8 mg kg-1). With the exception of K033, all of the tested K-oximes showed better therapeutic efficiency than HI-6 and TMB-4. K027 and K048 stood out by demonstrating low acute toxicities and ensuring protective indices ranging from 60.0 to 100.0 LD50 of paraoxon. Taking into account that these two oximes showed a similar therapeutic efficacy regardless of the applied doses, our results suggest that K027 and K048 could be perspective antidotes for paraoxon intoxication.
Published
2015-05-19
How to Cite
1.
Žunec S, Radić B, Kuča K, Musilek K, Lucić Vrdoljak A. Comparative determination of the efficacy of bispyridinium oximes in paraoxon poisoning. Arh Hig Rada Toksikol [Internet]. 2015May19 [cited 2024Dec.1];66(2). Available from: https://arhiv.imi.hr/index.php/arhiv/article/view/329
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Original article