Combined effects of valproate and naringin on kidney antioxidative markers and serum parameters of kidney function in C57BL6 mice

  • David Jutrić University of Zagreb Faculty of Science, Zagreb, Croatia
  • Domagoj Đikić Department of Animal Physiology, Faculty of Science, University of Zagreb
  • Almoš Boroš University of Zagreb Faculty of Science, Zagreb, Croatia
  • Dyana Odeh University of Zagreb Faculty of Science, Zagreb, Croatia
  • Romana Gračan University of Zagreb Faculty of Science, Zagreb, Croatia
  • Anđelo Beletić Genos Ltd., Glycoscience Research Laboratory, Zagreb, Croatia
  • Irena Landeka Jurčević University of Zagreb Faculty of Food Technology and Biotechnology, Zagreb, Croatia
Keywords: calcium, catalase, hyperkalaemia, malondialdehyde, oxidative stress, potassium, sodium, superoxide dismutase

Abstract

Valproate is known to disturb the kidney function, and high doses or prolonged intake may cause serum ion imbalance, kidney tubular acidosis, proteinuria, hyperuricosuria, polyuria, polydipsia, and dehydration. The aim of this in vivo study was to see whether naringin would counter the adverse effects of high-dose valproate in C57Bl/6 mice and to which extent. As expected, valproate (150 mg/kg bw a day for 10 days) caused serum hyperkalaemia, more in male than female mice. Naringin reversed (25 mg/kg bw a day for 10 days) the hyperkalaemia and activated antioxidative defence mechanisms (mainly catalase and glutathione), again more efficiently in females. In males naringin combined with valproate was not as effective and even showed some prooxidative effects.

Author Biography

Domagoj Đikić, Department of Animal Physiology, Faculty of Science, University of Zagreb

Associated professor

Department of Animal Physiology

Faculty of Science

University of Zagreb

Published
2023-09-25
How to Cite
1.
Jutrić D, Đikić D, Boroš A, Odeh D, Gračan R, Beletić A, Landeka Jurčević I. Combined effects of valproate and naringin on kidney antioxidative markers and serum parameters of kidney function in C57BL6 mice. Arh Hig Rada Toksikol [Internet]. 2023Sep.25 [cited 2024Jul.14];74(3). Available from: https://arhiv.imi.hr/index.php/arhiv/article/view/1620
Section
Original article

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