Glutathionylation: a regulatory role of glutathione in physiological processes

  • Kristina Dominko Institute Rudjer Bošković, Zagreb, Croatia
  • Domagoj Đikić Department of Animal Physiology, Faculty of Science, Univefrsity of Zagreb
Keywords: epigenetics, GLUTATHIONYLATION, GSH, TRANSCRIPTIONAL FACTORS, GSSG, IMMUNITY, immunity, transcriptional factors


Glutathione (γ-glutamyl-cysteinyl-glycine) is an intracellular thiol molecule and a potent antioxidant that participates in the toxic metabolism phase II biotransformation of xenobiotics. It can bind to a variety of proteins in a process known as glutathionylation. Protein glutathionylation is now recognised as one of important posttranslational regulatory mechanisms in cell and tissue physiology. Direct and indirect regulatory roles in physiological processes include glutathionylation of major transcriptional factors, eicosanoids, cytokines, and nitric oxide (NO). This review looks into these regulatory mechanisms through examples of glutathione regulation in apoptosis, vascularisation, metabolic processes, mitochondrial integrity, immune system, and neural physiology. The focus is on the physiological roles of glutathione beyond biotransformational metabolism.

Author Biography

Domagoj Đikić, Department of Animal Physiology, Faculty of Science, Univefrsity of Zagreb

Associated professor

Department of Animal Physiology

Faculty of Science

University of Zagreb



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How to Cite
Dominko K, Đikić D. Glutathionylation: a regulatory role of glutathione in physiological processes. Arh Hig Rada Toksikol [Internet]. 2018Mar.15 [cited 2022Oct.1];69(1). Available from: