Furan-induced hepatotoxic and hematologic changes in diabetic rats: the protective role of lycopene

  • Hatice Baş Bozok University, Faculty of Arts and Science, Department of Biology
  • Dilek Pandır Bozok University, Faculty of Arts and Science, Department of Biology
  • Suna Kalender Bozok University, Faculty of Arts and Science, Department of Biology
Keywords: diabetes, DNA damage, lycopene, hepatotoxicity, oxidative stress

Abstract

Furan forms as a result of thermal treatment of food and induces harmful effects on organisms. In our work, lycopene, furan, and a combination of the two were given to diabetic male rats for 28 days. Hematological changes, total protein and cholesterol, triglyceride, and albumin levels, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and alkaline phosphatase activities of the serum, malondialdehyde levels, glutathione peroxidase, catalase, glutathione-S-transferase, superoxide dismutase activities, DNA damage in liver tissues and hepatic histopathological alterations were compared to a control group. There were significant changes in the liver function tests, DNA damage, activities of antioxidant enzymes, and malondialdehyde levels between diabetic control and non-diabetic control groups, between diabetic control and diabetic lycopene groups, and also between diabetic furan and diabetic control groups. In diabetic lycopene and diabetic furan + lycopene treated groups we designated the preventive effects of lycopene against diabetes and furan, however, on the analysed parameters only. In spite of some pathological alterations designated in diabetic furan treated group's liver, fewer pathological alterations were observed in furan+lycopene treated groups at the end of week 4. Consequently, lycopene significantly reduced furan- and diabetes-induced toxicity in rat liver.
Published
2016-09-22
How to Cite
1.
Baş H, Pandır D, Kalender S. Furan-induced hepatotoxic and hematologic changes in diabetic rats: the protective role of lycopene. Arh Hig Rada Toksikol [Internet]. 2016Sep.22 [cited 2024Mar.28];67(3). Available from: https://arhiv.imi.hr/index.php/arhiv/article/view/500
Section
Original article