Ochratoxin A potentiates citrinin accumulation in kidney and liver of rats

  • Dubravka Rašić Institute for Medical Research and Occupational Health
  • Srđan Stefanović Institute of Meat Hygiene and Technology, Department for Residues, Belgrade, Serbia
  • Dragan Milićević Institute of Meat Hygiene and Technology, Department for Residues, Belgrade, Serbia
  • Marin Mladinić LEO Pharma, Preclinical Development, Ballerup, Denmark
  • Davor Želježić Institute for Medical Research and Occupational Health, Zagreb, Croatia
  • Alica Pizent Institute for Medical Research and Occupational Health, Zagreb, Croatia
  • Paško Konjevoda Rudjer Boskovic Institute, Division of Molecular Medicine, Zagreb,Croatia
  • Maja Peraica Institute for Medical Research and Occupational Health, Zagreb, Croatia
Keywords: experimental rats, mycotoxins, organic anion transporters, resveratrol, toxicity

Abstract

Ochratoxin A (OTA) and citrinin (CTN) are nephrotoxic mycotoxins often found together in grain. The aim of this study was to measure their accumulation in the kidney and liver of adult male Wistar rats, see how it would be affected by combined treatment, and to determine if resveratrol (RSV) would decrease their levels in these organs. The rats received 125 or 250 mg/kg bw of OTA by gavage every day for 21 days and/or 20 mg/kg bw of CTN a day for two days. Two groups of rats treated with OTA+CTN were also receiving 20 mg/kg bw of RSV a day for 21 days. In animals receiving OTA alone, its accumulation in both organs was dose-dependent. OTA+CTN treatment resulted in lower OTA but higher CTN accumulation in both organs at both OTA doses. RSV treatment increased OTA levels in the kidney and liver and decreased CTN levels in the kidney. Our findings point to the competition between CTN and OTA for organic anion transporters 1 and 3.

Published
2022-02-22
How to Cite
1.
Rašić D, Stefanović S, Milićević D, Mladinić M, Želježić D, Pizent A, Konjevoda P, Peraica M. Ochratoxin A potentiates citrinin accumulation in kidney and liver of rats. Arh Hig Rada Toksikol [Internet]. 2022Feb.22 [cited 2022Jun.30];73(1). Available from: https://arhiv.imi.hr/index.php/arhiv/article/view/1455
Section
Original article

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