Redox and biometal status in Wistar rats after subacute exposure to fluoride and selenium counter-effects

Authors

Jelena Radovanović University of Belgrade, Vinča Institute of Nuclear Sciences, Department of Radiobiology and Molecular Genetics, Belgrade, Serbia
Biljana Antonijević University of Belgrade Faculty of Pharmacy, Department of Toxicology "Akademik Danilo Soldatović", Belgrade, Serbia
Katarina Baralić University of Belgrade Faculty of Pharmacy, Department of Toxicology "Akademik Danilo Soldatović", Belgrade, Serbia
Marijana Ćurčić University of Belgrade Faculty of Pharmacy, Department of Toxicology "Akademik Danilo Soldatović", Belgrade, Serbia
Danijela Đukić-Ćosić University of Belgrade Faculty of Pharmacy, Department of Toxicology "Akademik Danilo Soldatović", Belgrade, Serbia
Zorica Bulat University of Belgrade Faculty of Pharmacy, Department of Toxicology "Akademik Danilo Soldatović", Belgrade, Serbia
Dragana Javorac University of Belgrade Faculty of Pharmacy, Department of Toxicology "Akademik Danilo Soldatović", Belgrade, Serbia
Aleksandra Buha Đorđević University of Belgrade Faculty of Pharmacy, Department of Toxicology "Akademik Danilo Soldatović", Belgrade, Serbia
Jelena Kotur-Stevuljević University of Belgrade Faculty of Pharmacy, Department of Biochemistry, Belgrade, Serbia
Emina Sudar-Milovanović University of Belgrade, Vinča Institute of Nuclear Sciences, Department of Radiobiology and Molecular Genetics, Belgrade, Serbia
Evica Antonijević Miljaković University of Belgrade Faculty of Pharmacy, Department of Toxicology "Akademik Danilo Soldatović", Belgrade, Serbia
Miloš Beloica University of Belgrade School of Dental Medicine, Clinic for Paediatric and Preventive Dentistry, Belgrade, Serbia
Zoran Mandinić University of Belgrade School of Dental Medicine, Clinic for Paediatric and Preventive Dentistry, Belgrade, Serbia

DOI:

https://doi.org/10.2478/aiht-2022-73-3650

Keywords:

Cu, Fe, MDA, NaF, O2-, oxidative stress, Se, SOD1, sodium fluoride, subacute toxicity, Zn

Abstract

This study aimed to investigate the effect of 150 mg/L sodium fluoride (NaF) on redox status parameters and essential metals [copper (Cu), iron (Fe), and zinc (Zn)] in the blood, liver, kidney, brain, and spleen of Wistar rats and to determine the protective potential of selenium (Se) against fluoride (F^-) toxicity. Male Wistar rats were randomly distributed in groups of five (n=5) receiving tap water (control) or water with NaF 150 mg/L, NaF 150 mg/L + Se 1.5 mg/L, and Se 1.5 mg/L solutions ad libitum for 28 days. Fluorides caused an imbalance in the redox and biometal (Cu, Fe, and Zn) status, leading to high superoxide anion (O₂^.-) and malondialdehyde (MDA) levels in the blood and brain and a drop in superoxide dismutase (SOD1) activity in the liver and its increase in the brain and kidneys. Se given with NaF improved MDA, SOD1, and O₂^.- in the blood, brain, and kidneys, while alone it decreased SH group levels in the liver and kidney. Biometals both reduced and increased F^- toxicity. Further research is needed before Se should be considered as a promising strategy for mitigating F^- toxicity.

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Published

15.09.2022

Issue

Vol. 73 No. 3 (2022)

Section

Original article

How to Cite

Radovanović J, Antonijević B, Baralić K, Ćurčić M, Đukić-Ćosić D, Bulat Z, et al. Redox and biometal status in Wistar rats after subacute exposure to fluoride and selenium counter-effects. Arh Hig Rada Toksikol [Internet]. 2022 Sep. 15 [cited 2026 Sep. 5];73(3). Available from: https://arhiv.imi.hr/index.php/arhiv/article/view/1500

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