Protective effects of resveratrol against fumonisin B1-induced liver toxicity in mice

Abstract

The aim of this study was to investigate the effects of resveratrol against fumonisin B₁ (FB₁)-induced liver toxicity, as, to the best of our knowledge, these effects have not been investigated yet, even though the toxic effects and mechanisms of FB₁ and the antioxidative effects of resveratrol are well known. 40 BALB/c mice were divided into control, FB₁, resveratrol, and FB₁+resveratrol groups. Control received saline for 14 days. The FB₁ group received 2.25 mg/kg FB₁ every other day for 14 days. The resveratrol group received 10 mg/kg resveratrol for 14 days. The FB₁+resveratrol group received 2.25 mg/kg FB₁ every other day and 10 mg/kg resveratrol every day for 14 days. All administrations were peritoneal. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), total sialic acid (TSA) levels were analysed in serum samples, while total antioxidant status (TAS) and total oxidant status (TOS) were measured in the liver. Additionally, the liver tissue was examined for histopathological changes. AST, ALT, and TSA were significantly higher in the FB₁ group than control. Resveratrol countered FB₁ effects for all parameters, including TOS and TAS. Liver histology showed FB₁-induced hyperaemia, infiltrations, and megalokaryosis in some hepatocytes. No pathological findings were detected in the control, resveratrol, or FB₁+resveratrol group. Our findings confirm resveratrol’s protective effect against liver damage and oxidative stress caused by FB₁. In addition, they suggest that increased serum TSA levels can be used as a biomarker of FB₁-induced hepatotoxicity.