Oxidative stress under general intravenous and inhalation anaesthesia

  • Sandra Alavuk Kundović
  • Dubravka Rašić
  • Ljiljana Popović
  • Maja Peraica IMI, Jedinica za toksikologiju
  • Ksenija Črnjar
Keywords: glutathione, malondialdehyde, reactive oxygene species, superoxide dismutase, TBARS

Abstract

Oxidative stress occurs when reactive oxygen species (ROS) production overwhelms cell protection by antioxidants. This review is focused on general anaesthesia-induced oxidative stress because it increases the rate of complications and delays recovery after surgery. It is important to know what effects of anaesthetics to expect in terms of oxidative stress, particularly in surgical procedures with high ROS production, because their either additive or antagonistic effect may be pivotal for the outcome of surgery. In vitro and animal studies on this topic are numerous but show large variability. There are not many human studies and what we know has been learned from different surgical procedures measuring different endpoints in blood samples taken mostly before and after surgery. In these studies most intravenous anaesthetics have antioxidative properties, while volatile anaesthetics temporarily increase oxidative stress in longer surgical procedures.

Published
2020-09-08
How to Cite
1.
Alavuk KundovićS, Rašić D, Popović L, Peraica M, Črnjar K. Oxidative stress under general intravenous and inhalation anaesthesia. Arh Hig Rada Toksikol [Internet]. 2020Sep.8 [cited 2020Dec.3];71(3). Available from: https://arhiv.imi.hr/index.php/arhiv/article/view/1291
Section
Review

Most read articles by the same author(s)