Can zinc supplementation ameliorate cadmium-induced alterations in the bioelement content in rabbits?

  • Zorica Bulat University of Belgrade, Faculty of Pharmacy, Department of Toxicology “Akademik Danilo Soldatović” http://orcid.org/0000-0001-9830-8772
  • Danijela Đukić-Ćosić University of Belgrade, Faculty of Pharmacy, Department of Toxicology “Akademik Danilo Soldatović”
  • Biljana Antonijević University of Belgrade, Faculty of Pharmacy, Department of Toxicology “Akademik Danilo Soldatović”
  • Aleksandra Buha University of Belgrade, Faculty of Pharmacy, Department of Toxicology “Akademik Danilo Soldatović”
  • Petar Bulat University of Belgrade, Faculty of Medicine, Institute of Occupational Health
  • Zoran Pavlović Institute for Public Health Pozarevac
  • Vesna Matović University of Belgrade, Faculty of Pharmacy, Department of Toxicology “Akademik Danilo Soldatović”
DOI: https://doi.org/10.1515/aiht-2017-68-2919
Keywords: Biometals, Biometals ratio, Bones, Copper, Kidney, Liver, Magnesium, Interactions

Abstract

The study was designed to investigate the influence of zinc (Zn) supplementation on cadmium-induced alterations in zinc, copper (Cu), and magnesium (Mg) status in rabbits. For this purpose, the concentrations of cadmium (Cd), Zn, Cu, and Mg were estimated in the blood, liver, kidney, and bone. The rabbits were divided in a control group, a Cd group-animals intoxicated orally with Cd (10 mg kg-1 bw, as aqueous solution of Cd-chloride), and a Cd+Zn group-animals intoxicated with the same dose of Cd and co-treated with Zn (20 mg kg-1 bw, as aqueous solution of Zn-sulphate). Solutions were administered orally, every day for 28 days. Sample mineralisation was performed with concentrated nitric acid (HNO3) and perchloric acid (HClO4) (4:1) and metal concentrations were determined by atomic absorption spectrophotometry (AAS). Zinc supplementation improved some of Cd-induced disturbances in bioelement levels in the investigated tissues. Beneficial effects of Zn on Zn and Cu levels were observed in blood, as well as on the Cu kidney level. The calculated values for Cu/Zn, Mg/Zn, and Mg/Cu ratios in blood suggest that Zn co-treatment reduces Cd-induced changes in bioelement ratios in blood.

Published
2017-03-16
How to Cite
1.
Bulat Z, Đukić-Ćosić D, Antonijević B, Buha A, Bulat P, Pavlović Z, Matović V. Can zinc supplementation ameliorate cadmium-induced alterations in the bioelement content in rabbits?. Arh Hig Rada Toksikol [Internet]. 2017Mar.16 [cited 2024Apr.20];68(1). Available from: https://arhiv.imi.hr/index.php/arhiv/article/view/685
Issue
Vol 68 No 1 (2017)
Section
Original article