Archives of Industrial Hygiene and Toxicology <div class="WordSection1"> <p><strong><em>Archives of Industrial Hygiene and Toxicology</em></strong> (Arh Hig Rada Toksikol) is an internationally peer-reviewed biomedical scientific quarterly that publishes contributions relevant to all aspects of environmental and occupational health and toxicology.</p> <p>Indexed in <strong>SCI Expanded</strong>,<strong> Medline</strong>/<strong>PubMed</strong>,<strong> Scopus</strong>, Animal Science Database, Biological Sciences (CSA), BIOSIS Previews, GreenFile, INIS, Pollution Abstracts, Veterinary Science Database, Water Resources Abstracts, EBSCO Academic Search Complete, TEMA, TOXLINE, AGRIS, Food Science and Technology Abstracts – FSTA, and Ergonomic Abstracts.</p> <p><em>Archives</em> is a member of, and subscribes to the principles of, the Committee on Publication Ethics (COPE).</p> <p>Impact Factor (2017):<strong> 1.117</strong></p> <p>5-year Impact Factor (2017):<strong><strong> 1.335</strong></strong></p> </div> en-US (Arhiv za higijenu rada i toksikologiju) (Makso Herman) Thu, 21 Mar 2019 10:27:22 +0100 OJS 60 Happy 70, Archives! – our mission and vision for the years to come <p>This year we turn 70! Lucky for journals, they don’t get old with volumes. In our case, quite the opposite. The idea of this editorial, however, is not to look so far back but to share with you – our readers and authors – where we see Archives in the years to come.</p> Dado Čakalo, Nevenka Kopjar ##submission.copyrightStatement## Thu, 21 Mar 2019 00:00:00 +0100 The role of physics in radioecology and radiotoxicology <p>This article gives an overview of physical concepts important for radioecology and radiotoxicology to help bridge a gap between non-physicists in these scientific disciplines and the intricate language of physics. Relying on description and only as much mathematics as necessary, we discuss concepts ranging from fundamental natural forces to applications of physical modelling in phenomenological studies. We first explain why some atomic nuclei are unstable and therefore transmute. Then we address interactions of ionising radiation with matter, which is the foundation of both radioecology and radiotoxicology. We continue with relevant naturally occurring and anthropogenic radionuclides and their properties, abundance in the environment, and toxicity for the humans and biota. Every radioecological or radiotoxicological assessment should take into account combined effects of the biological and physical half-lives of a radionuclide. We also outline the basic principles of physical modelling commonly used to study health effects of exposure to ionising radiation, as it is applicable to every source of radiation but what changes are statistical weighting factors, which depend on the type of radiation and exposed tissue. Typical exposure doses for stochastic and deterministic health effects are discussed, as well as controversies related to the linear no-threshold hypothesis at very low doses.</p> Branko Petrinec, Marko Šoštarić, Dinko Babić ##submission.copyrightStatement## Tue, 26 Feb 2019 11:32:43 +0100 Inhalation poisoning with palytoxin from aquarium coral: case description and safety advice <p><em>Palythoa</em> spp. corals and some other marine organisms contain one of the most poisonous substances ever known – palytoxin (PTX). Due to their modest life requirements and ease of breeding, these corals are popular in home aquariums. Here we refer to a case of PTX poisoning of a middle-aged woman who inhaled poisonous vapours while brushing the corals from live rock and compare it with the available literature. As the case revealed that the symptoms of PTX poisoning are not specific and neither is treatment, our aim was to give a brief tabulated review of the symptoms that may indicate such poisoning. Cases of palytoxin poisoning have been reported worldwide, and severe ones (mostly due to ingestion of contaminated sea food) can end in death. As it appears, most (if not all) poisonings result from unawareness of the risk and reckless handling by aquarists. This is one of the first articles which provides some practical advice about the use of personal protection equipment, including gloves, masks, eyewear, and other clothing during any coral manipulation to minimise the risk. We also draw attention to the lack of marketing/trading regulations for dangerous coral species and/or regulations or instructions dealing with their removal and health protection.</p> Aleksandra Łoś, Michał Schulz, Aneta Strachecka, Aleksandra Szabelak ##submission.copyrightStatement## Fri, 08 Mar 2019 10:34:23 +0100 Antioxidants and selenocompounds inhibit 3,5-dimethylaminophenol toxicity to human urothelial cells <p>Exposure to alkyl anilines may lead to bladder cancer, which is the second most frequent cancer of the urogenital tract. 3,5-dimethylaniline is highly used in industry. Studies on its primary metabolite 3,5-dimethylaminophenol (3,5-DMAP) showed that this compound causes oxidative stress, changes antioxidant enzyme activities, and leads to death of different mammalian cells. However, there is no in vitro study to show the direct effects of 3,5-DMAP on human bladder and urothelial cells. Selenocompounds are suggested to decrease oxidative stress caused by some chemicals, and selenium supplementation was shown to reduce the risk of bladder cancer. The main aim of this study was to investigate whether selenocompounds organic selenomethionine (SM, 10&nbsp;µmol/L) or inorganic sodium selenite (SS, 30&nbsp;nmol/L] could reduce oxidative stress, DNA damage, and apoptosis in UROtsa cells exposed to 3,5-DMAP. 3,5-DMAP caused a dose-dependent increase in intracellular generation of reactive oxygen species, and its dose of 50&nbsp;µmol/L caused lipid peroxidation, protein oxidation, and changes in antioxidant enzyme activities in different cellular fractions. The comet assay also showed single-strand DNA breaks induced by the 3,5-DMAP dose of 50&nbsp;µmol/L, but no changes in double-strand DNA breaks. Apoptosis was also triggered. Both selenocompounds provided partial protection against the cellular toxicity of 3,5-DMAP. Low selenium status along with exposure to alkyl anilines can be a major factor in the development of bladder cancer. More mechanistic studies are needed to specify the role of selenium in bladder cancer.</p> Pinar Erkekoglu, Ming-Wei Chao, Chia-Yi Tseng, Bevin P. Engelward, Ozge Kose, Belma Kocer-Gumusel, Gerald N. Wogan, Steven R. Tannenbaum ##submission.copyrightStatement## Mon, 25 Feb 2019 12:02:21 +0100 Effects of simvastatin and fenofibrate on butyrylcholinesterase activity in the brain, plasma, and liver of normolipidemic and hyperlipidemic rats <p>The study objective was to test the hypothesis that simvastatin and fenofibrate should cause an increase in butyrylcholinesterase (BuChE) activity not only in the plasma and liver but also in the brain of normolipidemic and hyperlipidemic rats. Catalytic enzyme activity was measured using acetylthiocholine (ATCh) and butyrylthiocholine (BTCh) as substrates. Normolipidemic and hyperlipidemic rats were divided in four groups receiving 50&nbsp;mg/kg of simvastatin a day or 30&nbsp;mg/kg of fenofibrate a day for three weeks and three control groups receiving saline. Simvastatin and fenofibrate caused an increase in brain BuChE activity in both normo- and hyperlipidemic rats regardless of the substrate. The increase with BTCh as substrate was significant and practically the same in normolipidemic and hyperlipidemic rats after simvastatin treatment (14–17% vs controls). Simvastatin and fenofibrate also increased liver and plasma BuChE activity in both normolipidemic and hyperlipidemic rats regardless of the substrate. In most cases the increase was significant. Considering the important role of BuChE in cholinergic transmission as well as its pharmacological function, it is necessary to continue investigations of the effects of lipid-lowering drugs on BuChE activity.</p> Antonija Vukšić, Jasna Lovrić, Paško Konjevoda, Nina Blažević, Marinko Bilušić, Vlasta Bradamante ##submission.copyrightStatement## Thu, 07 Feb 2019 10:23:41 +0100 The effects of occupational lead exposure on selected inflammatory biomarkers <p>In exposure to toxic metals such as lead, determining lead and cytokine levels (IL-6, IL-10, and TNF-α) is essential for early detection of diseases. The aim of this study was to develop an model for early detection of inflammation and onset of atherosclerosis in the absence of clinical findings in young workers, which could help physicians take timely an action and start treatment. This study included 49 metal workers exposed to lead occupationally and 50 unexposed administrative workers (controls) who underwent immunological analysis for cytokines (IL-6, IL-10, and TNF-α) and atherosclerosis markers (h-FABP and VCAM-1), toxicological analysis for lead, and routine biochemical analysis (ALT, AST, creatinine) at the Ankara Occupational and Environmental Diseases Hospital in 2017. Lead levels correlated with IL-6, IL-10, and TNF-α (r=0.469, r=0.521 and r=0.279, respectively, p&lt;0.01) but did not significantly affect h-FABP and VCAM-1 levels.</p> Vugar Ali Turksoy, Lutfiye Tutkun, Servet Birgin Iritas, Meside Gunduzoz, Serdar Deniz ##submission.copyrightStatement## Fri, 08 Mar 2019 14:35:32 +0100 Inspiratory muscle strength affects anaerobic endurance in professional athletes <p>To the best of our knowledge, little is known about the role of respiratory muscle strength and endurance on athlete performance in anaerobic conditions of maximal exertion. The aim of this cross-sectional study was therefore to examine the association between the strength/endurance of inspiratory muscles in a group of 70 healthy male professional athletes (team sports) and their ventilatory and metabolic parameters at the anaerobic threshold (second ventilatory threshold; VT2) and beyond it at maximum load during the cardiopulmonary exercise test (CPET) on a treadmill. Ventilatory parameters at VT2, at maximal effort, and their differences were tested for association with inspiratory muscle strength (PImax) and endurance (Tlim), measured as time to maintain inspiration at or above 80% of PImax. The difference in end-tidal oxygen tension (ΔPETO2) between VT2 and maximal effort was significantly associated with resting heart rate (HR) and systolic blood pressure (BP), PImax, and lean body mass (LBM) (r2=0.26, p=0.016; multivariate regression analysis). The difference in carbon dioxide output (ΔVCO2) was significantly associated with body mass index (BMI), resting HR, systolic BP, and PImax (r2=0.25, p=0.022; multivariate regression analysis). Our findings suggest that it is the inspiratory muscle strength and not endurance that affects the performance of professional athletes and that it should be tested and trained systematically.</p> Iva Jurić, Slavica Labor, Davor Plavec, Marina Labor ##submission.copyrightStatement## Fri, 01 Mar 2019 14:35:25 +0100 The effects of amiodarone prophylaxis on cardiac dysrhythmia in acute aluminium phosphide poisoning <p>Cardiovascular toxicity is the most common cause of fatality in the first 24 hours of poisoning with aluminium phosphide (AlP). Most often manifesting itself in cardiac dysrhythmias. The aim of this study was to evaluate the benefits of amiodarone prophylaxis against cardiac dysrhythmia in 46 patients with acute AlP poisoning. They were divided in two groups of 23: one receiving amiodarone and the other not (control). The treatment group received amiodarone prophylaxis in the initial intravenous bolus dose of 150&nbsp;mg, followed by a drip of 1&nbsp;mg/min for six hours and then of 0.5&nbsp;mg/min for eighteen hours. Both groups were Holter-monitored for 24 hours since admission. Save for amiodarone, both groups received the same standard treatment. Amiodarone had a significant beneficial effect in reducing the frequency of ST-segment elevation and ventricular fibrillation plus atrial fibrillation (P=0.02 and P=0.01, respectively), but the groups did not differ significantly in mortality (9 vs 11 patients, respectively). The mean time between ICU admission and death (survival time) was significantly longer in the treatment group (22 vs 10&nbsp;h, respectively; P=0.03). Regardless its obvious limitations, our study suggests that even though amiodarone alone did not reduce mortality, it may provide enough time for antioxidant therapy to tip the balance in favour of survival and we therefore advocate its prophylactic use within the first 24&nbsp;h of AlP poisoning.</p> Mohammad-Reza Beyranvand, Soleyman Farrokhi, Hassan Peyvandi, Kambiz Soltaninejad, Shahin Shadnia ##submission.copyrightStatement## Thu, 14 Feb 2019 10:31:56 +0100 The role of basic psychological needs in the perception of job insecurity <p>The aim of this study was to investigate whether satisfied basic psychological needs reduce the perception of threat generated by job insecurity, defined as self-assessment of the availability of the working role to its performers in the foreseeable future. The study included 310 participants employed in 24 companies, who completed the Perception of Job Insecurity Scale and Need Satisfaction Scale. The hypotheses were tested with multiple regression analyses. The results point to the importance of two basic needs – Autonomy and Competence – as factors that reduce the level of perceived job insecurity. This study broadens the understanding of personality resources as factors that moderate the perception of job insecurity and confirms the self-determination theory in the organisational context. Satisfying the needs for autonomy and competence can serve as a basis for interventions aimed at strengthening resilience to stress in employees.</p> Jasmina Knežević, Tatjana Krstić ##submission.copyrightStatement## Mon, 04 Feb 2019 15:22:19 +0100 Keeping children safe from harmful household products: a survey on safety practices in Croatia Željka Babić, Zrinka Franić, Jelena Macan ##submission.copyrightStatement## Mon, 28 Jan 2019 15:42:03 +0100 Metrology for the mobile detection of ionising radiation following a nuclear or radiological incident ‒ The EMPIR project “Preparedness” Stefan Neumaier, Harald Dombrowski, Patrick Kessler, Maksym Luchkov, Arturo Vargas, Steven Bell, Konstantins Bogucarskis, Petr Kovar ##submission.copyrightStatement## Wed, 06 Mar 2019 15:54:07 +0100 Report of the Poison Control Centre for the period from 1 January to 31 December 2018 Željka Babić, Jelena Kovačić, Rajka Turk ##submission.copyrightStatement## Mon, 18 Mar 2019 11:55:55 +0100