Dynamics of exhaled breath temperature after smoking a cigarette and its association with lung function changes predictive of COPD risk in smokers: a cross-sectional study

  • Ivana Huljev Šipoš Department of Pulmonology, General Hospital Šibenik, Croatia
  • Slavica Labor Department of Pulmonology, University Hospital Center Osijek, Croatia; Faculty of Medicine, J.J. Strossmayer University of Osijek, Croatia, Osijek, Croatia
  • Iva Jurić Department of Cardiology, University Hospital Center Osijek, Croatia
  • Davor Plavec Dječja bolnica Srebrnjak Medicinski fakultet Sveučilišta JJ Strossmayer Osijek
  • Kristian Vlahoviček Bioinformatics Group, Division of Molecular Biology, Department of Biology, Faculty of Science, University of Zagreb, Zagreb, Croatia
  • Siniša Bogović Department of Cardiac Surgery, University Hospital Center Osijek, Croatia
  • Justinija Pavkov Vukelić Department of Medicine, County General Hospital Našice, Našice, Croatia
  • Marina Labor Department of Pulmonology, University Hospital Center Osijek, Croatia; Faculty of Medicine, J.J. Strossmayer University of Osijek, Croatia, Osijek, Croatia
Keywords: EBT, cigarette smoke toxicity, cigarette smoking, COPD risk, small airway dysfunction

Abstract

Exhaled breath temperature (EBT) is a biomarker of inflammation and vascularity of the airways already shown to predict incident COPD. This cross-sectional study was aimed to assess the potential of EBT in identifying "healthy" smokers susceptible to cigarette smoke toxicity of the airways and to the risk of developing COPD by analysing the dynamics of EBT after smoking a cigarette and its associations with their demographics (age, smoking burden) and lung function. The study included 55 current smokers of both sexes, 29–62 years of age, with median smoking exposure of 15 (10–71.8) pack-years. EBT was measured at baseline and 5, 15, 30, 45, and 60 min after smoking a single cigarette. Lung function was measured with spirometry followed by a bronchodilator test. To compare changes in EBT between repeated measurements we used the analysis of variance and the area under the curve (EBTAUC) as a dependent variable. Multivariate regression analysis was used to look for associations with patient characteristics and lung function in particular. The average (±SD) baseline EBT was 33.42±1.50 °C. The highest significant increase to 33.84 (1.25) °C was recorded 5 min after the cigarette was smoked (p=0.003), and it took one hour for it to return to the baseline. EBTAUC showed significant repeatability (ICC=0.85, p<0.001) and was significantly associated with age, body mass index, number of cigarettes smoked a day, baseline EBT, and baseline FEF75 (R2=0.39, p<0.001 for the model). Our results suggest that EBT after smoking a single cigarette could be used as early risk predictor of changes associated with chronic cigarette smoke exposure.

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Published
2019-05-31
How to Cite
1.
Huljev Šipoš I, Labor S, Jurić I, Plavec D, Vlahoviček K, Bogović S, Pavkov Vukelić J, Labor M. Dynamics of exhaled breath temperature after smoking a cigarette and its association with lung function changes predictive of COPD risk in smokers: a cross-sectional study. Arh Hig Rada Toksikol [Internet]. 2019May31 [cited 2019Oct.23];70(2). Available from: https://arhiv.imi.hr/index.php/arhiv/article/view/1045
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