Antineoplastic DNA-Binding Compounds: Intercalating and Minor Groove Binding Drugs
Keywords:
chemotherapy, DNA intercalator, DNA minor groove binder, organic compounds derivatives
Abstract
DNAintercalating and minor groove binding compounds are new weapons in the battle against malignant diseases. These antineoplastic agents target theDNAmolecule and interfere with the cell cycle leading to rapidly proliferating cell death. They are mainly derivates of a naturally occurring organic compound derived from a microorganism or plant. Intercalators usually act as topoisomerase I and/or II poisons, while the mechanisms ofDNAminor groove binders are a combination of several steps including topoisomerase poisoning. This paper gives an overview of some of the developedDNAintercalating and minor groove binding compounds, as well as an explanation of their chemical structures, origins, and application in chemotherapy.
Published
2013-12-15
How to Cite
1.
Mišković K, Bujak M, Baus Lončar M, Glavaš-Obrovac L. Antineoplastic DNA-Binding Compounds: Intercalating and Minor Groove Binding Drugs. Arh Hig Rada Toksikol [Internet]. 2013Dec.15 [cited 2024Mar.28];64(4). Available from: https://arhiv.imi.hr/index.php/arhiv/article/view/104
Issue
Section
Review