Facts about phthalate toxicity in humans and their occurrence in alcoholic beverages

  • Irena Brčić Karačonji Analytical Toxicology and Mineral Metabolism Unit, Institute for Medical Research and Occupational Health
  • Sonja Anić Jurica Department of Gynecology and Obstetrics, University Hospital Centre Zagreb
  • Dario Lasić Department of Ecology, Teaching Institute of Public Health
  • Karlo Jurica Special Security Operations Directorate, Ministry of the Interior, Zagreb
Keywords: alcoholic drinks, phthalate legislative, endocrine disruptors, tolerably daily intake, maximum allowed concentration, tolerable daily intake


Phthalates are esters of phthalic acid and aliphatic alcohol added to plastic to improve its softness, flexibility, and extensibility. They easily migrate from plastic products into the environment because of their physical and chemical properties. This review summarises their characteristics, distribution in the environment, monitoring, use, toxic effects on human health, regulatory limits in different matrices and products, and tolerable daily intake. The studies we have reviewed suggest that phthalates have a potential to affect reproduction and development in humans. Due to the inconsistent data, further studies are needed and, in the meantime, precautionary policies must be implemented. Here we draw attention to the methods of determining phthalate levels in alcoholic beverages and reported levels in plum spirits produced in Croatia. Legally produced and moderately consumed plum spirits do not seem to increase the risk of phthalate toxicity for human health. We conclude with recommendations for the effective monitoring of phthalate exposure in humans and for the implementation of alternative materials in alcohol production.


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How to Cite
Brčić Karačonji I, Anić Jurica S, Lasić D, Jurica K. Facts about phthalate toxicity in humans and their occurrence in alcoholic beverages. AIHT [Internet]. 20Jun.2017 [cited 20Jul.2018];68(2). Available from: https://arhiv.imi.hr/index.php/arhiv/article/view/724