Cytogenetic Damage in Turkish Coke Oven Workers Exposed to Polycyclic Aromatic Hydrocarbons: Association with CYP1A1, CYP1B1, EPHX1, GSTM1, GSTT1, and GSTP1 Gene Polymorphisms

Authors

  • Ahmet Oguz Ada Department of Toxicology, Faculty of Pharmacy, Ankara University, Tandogan
  • Canan Demiroglu Department of Toxicology, Faculty of Pharmacy, Gazi University, Etiler
  • Meltem Yilmazer Department of Toxicology, Faculty of Pharmacy, Gazi University, Etiler
  • Halit Sinan Suzen Department of Toxicology, Faculty of Pharmacy, Ankara University, Tandogan
  • Ali Eba Demirbag Gastrointestinal Surgery Department, Yuksek Ihtisas Hospital, Sihhiye
  • Sibel Efe Eregli Iron and Steel Works Co., Karadeniz Eregli
  • Yilmaz Alemdar Eregli Iron and Steel Works Co., Karadeniz Eregli
  • Mumtaz Iscan Department of Toxicology, Faculty of Pharmacy, Ankara University, Tandogan
  • Sema Burgaz Department of Toxicology, Faculty of Pharmacy, Gazi University, Etiler

DOI:

https://doi.org/10.2478/10004-1254-64-2013-2328

Keywords:

chromosomal aberrations, biomarkers, micronuclei, occupational exposure

Abstract

The aim of this study was to determine the frequencies of chromosomal aberrations (CA) and cytochalasin-blocked micronuclei (CBMN) in peripheral blood lymphocytes from Turkish coke oven workers and the influence of CYP1A1, CYP1B1, EPHX1, GSTM1, GSTT1, and GSTP1 gene polymorphisms on these biomarkers. Cytogenetic analysis showed that occupational exposure significantly increased the CA and CBMN frequencies. Gene polymorphisms, on the other hand, did not affect CA or CBMN in either exposed or control subjects. However, due to the limited sample size, our findings need to be verified in future studies with a larger sample.

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Published

15.09.2013

Issue

Vol. 64 No. 3 (2013)

Section

Scientific Paper

How to Cite

1.
Cytogenetic Damage in Turkish Coke Oven Workers Exposed to Polycyclic Aromatic Hydrocarbons: Association with CYP1A1, CYP1B1, EPHX1, GSTM1, GSTT1, and GSTP1 Gene Polymorphisms. Arh Hig Rada Toksikol [Internet]. 2013 Sep. 15 [cited 2024 Dec. 22];64(3). Available from: https://arhiv.imi.hr/index.php/arhiv/article/view/72

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