Mutagenic and carcinogenic structural alerts and their mechanisms of action
Keywords:
carcinogenicity, mutagenicity, software prediction, toxicophores
Abstract
Knowing the mutagenic and carcinogenic properties of chemicals is very important for their hazard (and risk) assessment. One of the crucial events that trigger genotoxic and sometimes carcinogenic effects is the forming of adducts between chemical compounds and nucleic acids and histones. This review takes a look at the mechanisms related to specific functional groups (structural alerts or toxicophores) that may trigger genotoxic or epigenetic effects in the cells. We present up-to-date information about defined structural alerts with their mechanisms and the software based on this knowledge (QSAR models and classification schemes).
Published
2016-09-22
How to Cite
1.
Plošnik A, Vračko M, Sollner Dolenc M. Mutagenic and carcinogenic structural alerts and their mechanisms of action. Arh Hig Rada Toksikol [Internet]. 2016Sep.22 [cited 2024Apr.26];67(3). Available from: https://arhiv.imi.hr/index.php/arhiv/article/view/548
Issue
Section
Review