Melatonin Improves Liver Function in Benzene-Treated Rats

  • Seema Sharma Toxicology Laboratory, Department of Zoology, Ch. Charan Singh University Meerut, Meerut, India
  • Suresh Vir Singh Rana Toxicology Laboratory, Department of Zoology, Ch. Charan Singh University Meerut, Meerut, India
DOI: https://doi.org/10.2478/10004-1254-64-2013-2248
Keywords: alkaline phosphatase, antioxidants, bilirubin, hydroxyproline, serum transaminases

Abstract

In this study, we investigated the beneficial effects of melatonin against benzene-induced liver function impairments in Wistar rats. After 30 days of treatment, it significantly lowered hepatosomatic indices, bilirubin, and hydroxyproline in male and female benzene-treated rats. Even though it did not influence aspartate aminotransferase, melatonin had beneficial effects on alanine aminotransferase and alkaline phosphatase. Our results suggest that melatonin is an effective modulator of liver function in benzene-treated rats thanks to its antioxidative properties.
Published
2013-05-24
How to Cite
1.
Sharma S, Rana SVS. Melatonin Improves Liver Function in Benzene-Treated Rats. Arh Hig Rada Toksikol [Internet]. 2013May24 [cited 2024Apr.20];64(2). Available from: https://arhiv.imi.hr/index.php/arhiv/article/view/49
Issue
Vol 64 No 2 (2013)
Section
Scientific Paper