Melatonin Improves Liver Function in Benzene-Treated Rats

Authors

  • Seema Sharma Toxicology Laboratory, Department of Zoology, Ch. Charan Singh University Meerut, Meerut, India
  • Suresh Vir Singh Rana Toxicology Laboratory, Department of Zoology, Ch. Charan Singh University Meerut, Meerut, India

DOI:

https://doi.org/10.2478/10004-1254-64-2013-2248

Keywords:

alkaline phosphatase, antioxidants, bilirubin, hydroxyproline, serum transaminases

Abstract

In this study, we investigated the beneficial effects of melatonin against benzene-induced liver function impairments in Wistar rats. After 30 days of treatment, it significantly lowered hepatosomatic indices, bilirubin, and hydroxyproline in male and female benzene-treated rats. Even though it did not influence aspartate aminotransferase, melatonin had beneficial effects on alanine aminotransferase and alkaline phosphatase. Our results suggest that melatonin is an effective modulator of liver function in benzene-treated rats thanks to its antioxidative properties.

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Published

24.05.2013

Issue

Vol. 64 No. 2 (2013)

Section

Scientific Paper

How to Cite

1.
Melatonin Improves Liver Function in Benzene-Treated Rats. Arh Hig Rada Toksikol [Internet]. 2013 May 24 [cited 2024 Dec. 22];64(2). Available from: https://arhiv.imi.hr/index.php/arhiv/article/view/49