Characteristics of unintentional ingestion of oral non-steroidal anti-inflammatory drugs and analgesics in preschool children

Authors

  • Željka Babić Institute for Medical Research and Occupational Health, Zagreb
  • Nikolina Benco Kordić Children’s Hospital Zagreb, Department for Pediatric Clinical Pharmacology and Toxicology, Zagreb, Croatia
  • Arnes Rešić Children’s Hospital Zagreb, Department for Pediatric Clinical Pharmacology and Toxicology, Zagreb, Croatia; University of Split, University Department of Health Studies, Split, Croatia
  • Rajka Turk Institute for Medical Research and Occupational Health, Croatian Poison Control Centre, Zagreb, Croatia

DOI:

https://doi.org/10.2478/aiht-2021-72-3596

Keywords:

diclofenac, ibuprofen, ketoprofen, NSAIDs, overdose, paracetamol, poisoning, toddlers

Abstract

We characterised accidental ingestion of non-steroidal anti-inflammatory drugs and non-opioid analgesics in children aged 0–5 years between 2009 and 2019 by analysing records of telephone consultations with the Croatian Poison Control Centre (CPCC) and cases treated at the Children's Hospital Zagreb (CHZ). Among the total of 466 identified cases (411 from CPPCC records and 55 from CHS hospital records), the most frequently ingested drugs were ibuprofen (47 %), paracetamol (20 %), ketoprofen (15 %), and diclofenac (11 %). In 94 % of the cases unsupervised children ingested the drug left within their reach. The remaining 6 % were dosing errors by parents or caregivers and involved liquid formulations as a rule. Our findings can serve as real-life examples informing preventive measures.

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Published

23.12.2021

Issue

Vol. 72 No. 4 (2021)

Section

Original article

How to Cite

1.
Characteristics of unintentional ingestion of oral non-steroidal anti-inflammatory drugs and analgesics in preschool children. Arh Hig Rada Toksikol [Internet]. 2021 Dec. 23 [cited 2025 Jan. 22];72(4). Available from: https://arhiv.imi.hr/index.php/arhiv/article/view/1446

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