Characteristics of unintentional ingestion of oral non-steroidal anti-inflammatory drugs and analgesics in preschool children

Authors

Željka Babić Institute for Medical Research and Occupational Health, Zagreb
Nikolina Benco Kordić Children’s Hospital Zagreb, Department for Pediatric Clinical Pharmacology and Toxicology, Zagreb, Croatia
Arnes Rešić Children’s Hospital Zagreb, Department for Pediatric Clinical Pharmacology and Toxicology, Zagreb, Croatia; University of Split, University Department of Health Studies, Split, Croatia
Rajka Turk Institute for Medical Research and Occupational Health, Croatian Poison Control Centre, Zagreb, Croatia

DOI:

https://doi.org/10.2478/aiht-2021-72-3596

Keywords:

diclofenac, ibuprofen, ketoprofen, NSAIDs, overdose, paracetamol, poisoning, toddlers

Abstract

We characterised accidental ingestion of non-steroidal anti-inflammatory drugs and non-opioid analgesics in children aged 0–5 years between 2009 and 2019 by analysing records of telephone consultations with the Croatian Poison Control Centre (CPCC) and cases treated at the Children's Hospital Zagreb (CHZ). Among the total of 466 identified cases (411 from CPPCC records and 55 from CHS hospital records), the most frequently ingested drugs were ibuprofen (47 %), paracetamol (20 %), ketoprofen (15 %), and diclofenac (11 %). In 94 % of the cases unsupervised children ingested the drug left within their reach. The remaining 6 % were dosing errors by parents or caregivers and involved liquid formulations as a rule. Our findings can serve as real-life examples informing preventive measures.

Downloads

PDF

Published

23 December, 2021

Issue

Vol. 72 No. 4 (2021)

Section

Original article

How to Cite

1.

Babić Ž, Benco Kordić N, Rešić A, Turk R. Characteristics of unintentional ingestion of oral non-steroidal anti-inflammatory drugs and analgesics in preschool children. Arh Hig Rada Toksikol [Internet]. 2021 Dec. 23 [cited 2026 Oct. 12];72(4). Available from: https://arhiv.imi.hr/index.php/arhiv/article/view/1446

Download Citation

Similar Articles

Nada Božina, Lana Ganoci, Livija Simicevic, Katarina Gvozdanovic, Iva Klarica Domjanovic, Margareta Fistrek Prlic, Tena Kriz, Ana Boric Bilusic, Mario Laganovic, Tamara Bozina, Drug-drug-gene interactions as mediators of adverse drug reactions to diclofenac and statins: a case report and literature review , Archives of Industrial Hygiene and Toxicology: Vol. 72 No. 2 (2021)
Valon Krasniqi, Aleksandar Dimovski, Nada Božina, How polymorphisms of the cytochrome P450 genes affect ibuprofen and diclofenac metabolism and toxicity , Archives of Industrial Hygiene and Toxicology: Vol. 67 No. 1 (2016)
Tanja Kovačević, Branka Polić, Tatjana Ćatipović Ardalić, Davor Petrović, Luka Stričević, Joško Markić, A suicide attempt by ingestion of oleander leaves and treatment with digoxin-specific Fab antibody fragments , Archives of Industrial Hygiene and Toxicology: Vol. 74 No. 4 (2023)
Dražen Lušić, Sara Bezak, Irena Brčić Karačonji, What is more common in fatal caffeine intoxication – suicide or unintentional overdose? , Archives of Industrial Hygiene and Toxicology: Vol. 75 No. 4 (2024)
Snežana Đorđević, Nataša Perković Vukčević, Marko Antunović, Vesna Kilibarda, Vesna Kilibarda, Gordana Vuković Ercegović, Jasmina Jović Stošić, Slavica Vučinić, Olanzapine poisoning in patients treated at the National Poison Control Centre in Belgrade, Serbia in 2017 and 2018: a brief review of serum concentrations and clinical symptoms , Archives of Industrial Hygiene and Toxicology: Vol. 73 No. 2 (2022)
Emin Veledar, Željka Babić, Jelena Macan, Poisoning with biocidal products before and after the COVID-19 pandemic: report from the Croatian Poison Control Centre , Archives of Industrial Hygiene and Toxicology: Vol. 76 No. 4 (2025)
David Toma, Tania-Emima Toma, Cristina Bologa, Cătălina Lionte, Unusual aetiology of a type 2 myocardial infarction: a case-based review , Archives of Industrial Hygiene and Toxicology: Vol. 72 No. 1 (2021)
Yiming Tao, Xiangdong Jian, Skin burns from monochloroacetic acid leak in a chemical plant: a case report: Skin burns from monochloroacetic acid , Archives of Industrial Hygiene and Toxicology: Vol. 71 No. 2 (2020)
Željka Babić, Rajka Turk, Jelena Macan, Toxicological aspects of increased use of surface and hand disinfectants in Croatia during the COVID-19 pandemic: a preliminary report , Archives of Industrial Hygiene and Toxicology: Vol. 71 No. 3 (2020)
Roshan Kumar Sahu, Bhupendra Singh, Shubhini A. Saraf, Gaurav Kaithwas, Kamal Kishor, Photochemical toxicity of drugs intended for ocular use , Archives of Industrial Hygiene and Toxicology: Vol. 65 No. 2 (2014)

1-10 of 55 Next

You may also start an advanced similarity search for this article.

Most read articles by the same author(s)

Tea Samardžić, Roko Žaja, Željka Babić, Jelena Macan, Workplace risk assessment criteria for pregnant workers exposed to physical exertion and biological and chemical hazards , Archives of Industrial Hygiene and Toxicology: Vol. 76 No. 2 (2025)
Andreja Jurič, Blanka Tariba Lovaković, Antonio Zandona, Dubravka Rašić, Martin Česi, Alica Pizent, Marijana Neuberg, Irena Canjuga, Maja Katalinić, Ana Lucić Vrdoljak, Arnes Rešić, Irena Brčić Karačonji, The effects of ketamine on viability, primary DNA damage, and oxidative stress parameters in HepG2 and SH-SY5Y cells , Archives of Industrial Hygiene and Toxicology: Vol. 74 No. 2 (2023)
Željka Babić, Franka Šakić, Iva Japudžić Rapić, Liborija Lugović-Mihić, Jelena Macan, Difference between hand and forearm transepidermal water loss and skin pH as an improved method to biomonitor occupational hand eczema: our findings in healthcare workers , Archives of Industrial Hygiene and Toxicology: Vol. 75 No. 3 (2024)
Željka Babić, Tea Samardžić, Jelena Macan, Comparison of beautician and hairdressing apprentices with regard to skin health and skin barrier function , Archives of Industrial Hygiene and Toxicology: Vol. 71 No. 3 (2020)
Željka Babić, Rajka Turk, Jelena Macan, Toxicological aspects of increased use of surface and hand disinfectants in Croatia during the COVID-19 pandemic: a preliminary report , Archives of Industrial Hygiene and Toxicology: Vol. 71 No. 3 (2020)
Željka Babić, Zrinka Franić, Jelena Macan, Keeping children safe from harmful household products: a survey on safety practices in Croatia , Archives of Industrial Hygiene and Toxicology: Vol. 70 No. 1 (2019)
Veda Marija Varnai, Željka Babić, Rajka Turk, Izvješće Centra za kontrolu otrovanja za razdoblje od 1. siječnja do 31. prosinca 2012. / Report of the Poison Control Centre for the Period 1 January - 31 December 2012 , Archives of Industrial Hygiene and Toxicology: Vol. 64 No. 1 (2013)
Željka Babić, Jelena Kovačić, Rajka Turk, Report of the Poison Control Centre for the period from 1 January to 31 December 2018 , Archives of Industrial Hygiene and Toxicology: Vol. 70 No. 1 (2019)
Emin Veledar, Željka Babić, Jelena Macan, Poisoning with biocidal products before and after the COVID-19 pandemic: report from the Croatian Poison Control Centre , Archives of Industrial Hygiene and Toxicology: Vol. 76 No. 4 (2025)
Jelena Kovačić, Željka Babić, Rajka Turk, Izvješće Centra za kontrolu otrovanja za razdoblje od 1. siječnja do 31. prosinca 2014. / Report of the Poison Control Centre for the period from 1 January to 31 December 2014 , Archives of Industrial Hygiene and Toxicology: Vol. 66 No. 1 (2015)

1 2 > >>