Efficiency of hepatocyte pretreatment with coenzyme Q10 against statin toxicity

Authors

  • Mohammad Ali Eghbal Drug Applied Research Centre, Biotechnology Research Centre, Pharmacology and Toxicology Department, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz
  • Narges Abdoli Biotechnology Research Centre, Pharmacology and Toxicology Department, School of Pharmacy, Students' Research Committee, Tabriz University of Medical Sciences, Tabriz
  • Yadollah Azarmi Biotechnology Research Centre, Pharmacology and Toxicology Department, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz

DOI:

https://doi.org/10.2478/10004-1254-65-2014-2398

Keywords:

atorvastatin, hepatotoxicity, lipid peroxidation, lovastatin, oxidative stress, reactive oxygen species, simvastatin

Abstract

Statins are potent cholesterol-lowering drugs that can have serious adverse effects on the muscles and liver. The aim of our in vitro study was to establish the protective effect of coenzyme Q10 (CoQ10, in its optimal dose of 200 µmol L-1) against cytotoxicity induced by atorvastatin, simvastatin, and lovastatin in isolated rat hepatocytes by observing parameters such as cell death, reactive oxygen species formation, lipid peroxidation, mitochondrial membrane potential, and cellular reduced and oxidised glutathione content. Our findings have shown that pretreatment with CoQ10 was effective in reducing the toxic effects of statins in rat hepatocytes. This work demonstrates that the addition of CoQ10 to statin treatment regimens may protect hepatocytes (and also other types of cells) from statin-induced injuries and alleviate their side effects.

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Published

15.03.2014

Issue

Vol. 65 No. 1 (2014)

Section

Original article

How to Cite

1.
Efficiency of hepatocyte pretreatment with coenzyme Q10 against statin toxicity. Arh Hig Rada Toksikol [Internet]. 2014 Mar. 15 [cited 2024 Dec. 21];65(1). Available from: https://arhiv.imi.hr/index.php/arhiv/article/view/131