Efficiency of hepatocyte pretreatment with coenzyme Q10 against statin toxicity

  • Mohammad Ali Eghbal Drug Applied Research Centre, Biotechnology Research Centre, Pharmacology and Toxicology Department, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz
  • Narges Abdoli Biotechnology Research Centre, Pharmacology and Toxicology Department, School of Pharmacy, Students' Research Committee, Tabriz University of Medical Sciences, Tabriz
  • Yadollah Azarmi Biotechnology Research Centre, Pharmacology and Toxicology Department, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz
DOI: https://doi.org/10.2478/10004-1254-65-2014-2398
Keywords: atorvastatin, hepatotoxicity, lipid peroxidation, lovastatin, oxidative stress, reactive oxygen species, simvastatin

Abstract

Statins are potent cholesterol-lowering drugs that can have serious adverse effects on the muscles and liver. The aim of our in vitro study was to establish the protective effect of coenzyme Q10 (CoQ10, in its optimal dose of 200 µmol L-1) against cytotoxicity induced by atorvastatin, simvastatin, and lovastatin in isolated rat hepatocytes by observing parameters such as cell death, reactive oxygen species formation, lipid peroxidation, mitochondrial membrane potential, and cellular reduced and oxidised glutathione content. Our findings have shown that pretreatment with CoQ10 was effective in reducing the toxic effects of statins in rat hepatocytes. This work demonstrates that the addition of CoQ10 to statin treatment regimens may protect hepatocytes (and also other types of cells) from statin-induced injuries and alleviate their side effects.
Published
2014-03-15
How to Cite
1.
Eghbal MA, Abdoli N, Azarmi Y. Efficiency of hepatocyte pretreatment with coenzyme Q10 against statin toxicity. Arh Hig Rada Toksikol [Internet]. 2014Mar.15 [cited 2024Apr.26];65(1). Available from: https://arhiv.imi.hr/index.php/arhiv/article/view/131
Issue
Vol 65 No 1 (2014)
Section
Original article