Ferroptosis: regulated cell death

  • Ivana Čepelak Department of Medical Biochemistry and Hematology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
  • Slavica Dodig Department of Medical Biochemistry and Hematology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
  • Daniela Čepelak Dodig Croatian Institute of Public Health – Department for Toxicology, Zagreb, Croatia
Keywords: glutathione peroxidase 4, iron, lipid peroxidation, reactive oxygen species, system Xc-

Abstract

Ferroptosis is a recently identified form of regulated cell death that differs from other known forms of cell death morphologically, biochemically, and genetically. The main properties of ferroptosis are free redox-active iron and consequent iron-dependent peroxidation of polyunsaturated fatty acids in cell membrane phospholipids, which results in the accumulation of lipid-based reactive oxygen species due to loss of glutathione peroxidase 4 activity. Ferroptosis has increasingly been associated with neurodegenerative diseases, carcinogenesis, stroke, intracerebral haemorrhage, traumatic brain injury, and ischemia-reperfusion injury. It has also shown a significant therapeutic potential in the treatment of cancer and other diseases. This review summarises current knowledge about and the mechanisms that regulate ferroptosis.

Published
2020-05-13
How to Cite
1.
Čepelak I, Dodig S, Čepelak DodigD. Ferroptosis: regulated cell death. Arh Hig Rada Toksikol [Internet]. 2020May13 [cited 2020Jul.13];71(2). Available from: https://arhiv.imi.hr/index.php/arhiv/article/view/1211
Section
Review