Athlete biological passport: longitudinal biomarkers and statistics in the fight against doping

  • Dora Dragčević University Hospital Merkur, Department of Haematology, Zagreb, Croatia
  • Vlatka Pandžić Jakšić University Hospital Dubrava, Department of Endocrinology, Zagreb, Croatia
  • Ozren Jakšić University of Zagreb School of Medicine, Zagreb, Croatia; University Hospital Zagreb, Department of Haematology, Zagreb, Croatia
Keywords: ABP, biochemical factors, confounding factors, haematological module, steroidal module

Abstract

As novel substances, short time windows, and limits of detection increasingly challenge direct methods of doping detection in sports, indirect tools inevitably take a greater role in the fight against it. One such tool is the athlete biological passport (ABP) – a longitudinal profiling of the measured haematological and biochemical biomarkers, combined with calculated scores, against the background of epidemiological data crucial for doping detection. In both of its modules, haematological and steroidal, ABP parameters are analysed with the Bayesian adaptive model, which individualises reference and cut-off values to improve its sensitivity. It takes into account the confounding factors with proven and potential influence on the biomarkers, such as race and altitude exposure. The ABP has already changed the fight against doping, but its importance will further grow with the new modules (e.g., endocrinological), parameters (e.g., plasma volume-independent parameters), and complementing indirect methods (e.g., transcriptomic).

Published
2024-02-28
How to Cite
1.
Dragčević D, Pandžić Jakšić V, Jakšić O. Athlete biological passport: longitudinal biomarkers and statistics in the fight against doping. Arh Hig Rada Toksikol [Internet]. 2024Feb.28 [cited 2024May20];75(1). Available from: https://arhiv.imi.hr/index.php/arhiv/article/view/1655
Section
Review